Institutional ownership · Form 13F
GPCR institutional ownership
Structure Therapeutics Inc. - American Depositary Shares: reported institutional holdings as of 2026-06-30 (filed through 2026-08-31), aggregated by StockEyes from SEC Form 13F information tables. GPCR is one of 2732 tickers in the validated publication set. Mapping coverage in this publication set: 4562 of 6046 universe tickers have at least one validated CUSIP mapping (75.5%). Latest-quarter filed value resolved to any listed ticker: 77.3%; resolved to this universe: 77.2%.
GPCR: change since the prior quarter's filings
The number of reporting managers slipped from 195 in the quarter ended 2026-03-31 to 192 in the quarter ended 2026-06-30 (-3, 1.5%). Total reported shares rose to 67,596,599 (+631,918, 0.9%), against the direction of the manager count. Among the 24 managers listed as top holders in both quarters, the largest increases were ORBIMED ADVISORS LLC (+733,997 shares) and MORGAN STANLEY (+501,183 shares), among 11 managers who added shares, and the largest decreases were FMR LLC (-593,143 shares) and Siren, L.L.C. (-455,731 shares), among 8 managers who reduced shares. Jupiter Topco LLC (5,204,212 shares), RTW INVESTMENTS, LP (1,607,507 shares) and 4 more entered the listed top holders; JANUS HENDERSON GROUP PLC (5,354,981 shares in the prior quarter), Paradigm Biocapital Advisors LP (545,287 shares in the prior quarter) and 4 more dropped out of the listed top holders.
New to 13F data? Read how to read a 13F filing, or see where institutions moved overall in the Smart Money Report.
Reported totals, quarter ended 2026-06-30
192 reporting managers held 67,596,599 shares, reported value $3,575,075,699 exactly as filed. Values are position values transcribed from the filings, not current market prices.
Reported quarter-over-quarter change (quarter ended 2026-03-31 to quarter ended 2026-06-30): reporting managers -3, reported shares +631,918 (+0.94%), reported value +14.03%. These changes compare two filing snapshots.
Shares outstanding check: 217,957,000 shares reported by the issuer (SEC XBRL, period ended 2026-06-30). Reported 13F shares equal 31.0% of that figure. This page passed the publication sanity gate before listing.
GPCR in this quarter's filings
Concentration check: the largest reported position, FMR LLC with 7,810,306 shares, is 11.6% of all shares reported for GPCR this quarter. The five largest reporting managers together account for 46.9% of the reported total, so the headline total is spread across a broad manager base rather than a few holders.
Reported quarter-over-quarter change: the reporting-manager count fell by 3 versus the quarter ended 2026-03-31, and reported shares moved +0.94% (+631,918 shares). That is a comparison of two filing snapshots, not a record of trades on any single day.
Shares-outstanding cross-check: reported 13F shares equal 31.0% of the issuer share count used at the publication gate (217,957,000 shares, issuer period ended 2026-06-30). The gate publishes a ticker only when that relationship is plausible; lending chains can push reported totals above a simple ownership share, which is why the figure is a sanity check and not an ownership percentage.
Largest reporting managers, GPCR
| # | Manager | Shares | Value as filed | Share of reported total |
|---|---|---|---|---|
| 1 | FMR LLC | 7,810,306 | $419,179,123 | 11.6% |
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 7,379,433 | $396,054,169 | 10.9% |
| 3 | Avoro Capital Advisors LLC | 6,555,555 | $351,836,637 | 9.7% |
| 4 | Jupiter Topco LLC | 5,204,212 | $279,339,383 | 7.7% |
| 5 | Deep Track Capital, LP | 4,740,072 | $254,399,664 | 7.0% |
| 6 | BVF INC/IL | 3,366,823 | $180,697,390 | 5.0% |
| 7 | MORGAN STANLEY | 2,806,640 | $150,632,372 | 4.2% |
| 8 | ORBIMED ADVISORS LLC | 2,209,400 | $118,578,498 | 3.3% |
| 9 | PRINCIPAL FINANCIAL GROUP INC | 1,752,753 | $94,070,254 | 2.6% |
| 10 | AMERICAN CENTURY COMPANIES INC | 1,682,179 | $90,282,956 | 2.5% |
| 11 | RTW INVESTMENTS, LP | 1,607,507 | $86,274,901 | 2.4% |
| 12 | Driehaus Capital Management LLC | 1,553,219 | $83,361,264 | 2.3% |
| 13 | BAKER BROS. ADVISORS LP | 1,432,529 | $76,883,831 | 2.1% |
| 14 | Casdin Capital, LLC | 1,175,000 | $63,062,250 | 1.7% |
| 15 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,086,000 | $58,285,620 | 1.6% |
Manager names and figures are transcribed from each manager's own Form 13F information table. A manager listing shares in this snapshot does not mean it holds them today.
Reported change, 2026-03-31 to 2026-06-30
| Quarter ended | Filed through | Reporting managers | Reported shares | Value as filed |
|---|---|---|---|---|
| 2026-03-31 | 2026-05-29 | 195 | 66,964,681 | $3,135,214,778 |
| 2026-06-30 | 2026-08-31 | 192 | 67,596,599 | $3,575,075,699 |
Every change figure on this page is a reported quarter-over-quarter change between filing snapshots. It is not real-time trading activity.
GPCR reported totals over time
Quarter ended 2026-06-30: 192 reporting managers · 67,596,599 reported shares · $3,575,075,699 value as filed.
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Quarter-end 13F filed data, long positions only; filings arrive up to 45 days after quarter end.
CUSIPs behind the GPCR total
The validated bridge mapped 1 current CUSIP(s) to GPCR for this quarter: 86366E106. Option pseudo-CUSIPs, units, warrants, and preferred classes are excluded from these common-share totals. Mapping coverage in this publication set: 4562 of 6046 universe tickers have at least one validated CUSIP mapping (75.5%). Latest-quarter filed value resolved to any listed ticker: 77.3%; resolved to this universe: 77.2%.
What this page is and is not
Form 13F reports are quarterly holdings snapshots. Managers file up to about 45 days after quarter-end, so these figures describe reported positions as of the quarter-end date, not holdings today. 13F lists reportable long positions from managers above the SEC reporting threshold and omits short positions entirely.
This page is informational only. It is not investment advice, a recommendation, or a signal to buy or sell. Source: SEC Form 13F bulk data set for filings through 2026-08-31 (period ended 2026-06-30), joined to tickers through StockEyes' validated CUSIP bridge. Methodology and coverage are documented on the institutional ownership hub.
Insider transactions for GPCR (officer and director buys and sells) are covered by InsiderTrace: insidertrace.com/stock/gpcr. StockEyes does not duplicate insider transaction tables.
Related StockEyes pages
Latest headlines tagged GPCR are on the market news wire. Upcoming earnings and market dates are on the events calendar. The term itself is defined in the institutional investor glossary entry, and the research workflow behind pages like this one is walked through in how to research a stock and how to compare SEC filings.